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We all blame our genes for many of our features, behaviours and illnesses. Recent studies suggest that the environment before birth is also a major influence on the risk of ill-health across the lifespan and perhaps into a further generation. This process, called ‘developmental programming’, has been studied intensively in recent years and is beginning to reveal a process called epigenetics which underpins growth, behaviour and health risks. In this seminar, Prof Seckl will discuss these issues and how for example, stress during pregnancy or how well a child’s grandfather ate, impacts on their life.